1. Medications: Long-term use of high doses of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) -prescription painkillers, that contain ibuprofen (Advil®, Motrin®), naproxen (Aleve®), or acetaminophen (Tylenol®), has a harmful effect on kidney tissue and structures, causing shrinkage of blood vessels in the kidneys. Diuretics (urine enhancers) medications may also cause excessive water loss, straining the kidneys.
